An overturned tanker carrying as much as 3,000 gallons of slurry has closed the A30 eastbound at Scorrier.
Emergency services were called to the scene at 10.20am after a road traffic collision was reported on the eastbound slip road.
A second tanker is currently clearing up the lorry's "load" according to police officers.
The Exeter-bound carriageway of the A30 is closed and won't reopen until lunchtime, the police estimate.
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