Cornwall's Jack Nowell will make his Six Nations debut for England against France in Paris on Saturday.
The 20 year-old Exeter Chiefs player will start on the right wing for Stuart Lancaster's side in the absence of Chris Ashton, who was not named in the squad.
Head coach Lancaster said: "We can't wait for Saturday. Jack and Luther deserve their chance, as does Jonny May, who will be starting his first RBS Six Nations game."
Nowell's inclusion is one of four changes made to the back line ahead of the game at the Stade de France.
England's pack remains unchanged from the one which started against New Zealand in November.
England: Mike Brown; Jack Nowell, Luther Burrell, Billy Twelvetrees, Jonny May; Owen Farrell, Danny Care; Joe Marler, Dylan Hartley, Dan Cole, Joe Launchbury, Courtney Lawes, Tom Wood, Chris Robshaw, Billy Vunipola.
Replacements: Tom Youngs, Mako Vunipola, Henry Thomas, Dave Attwood, Ben Morgan, Lee Dickson, Brad Barritt, Alex Goode.