Daniel Sturridge was left "heartbroken" after suffering a thigh injury that ruled him out of England's Euro 2016 qualifier against Switzerland.
Sturridge pulled up during England's training session at St George's Park and scans later revealed the striker would be unable to travel to Basle for the game on Monday.
The striker was clearly devastated by the news, tweeting on Friday evening: "Heartbroken soul right now believe me. Hopefully be back soon fighting fit for LFC. Nothing worse than being injured. My heads gone..."
The Football Association would not reveal the extent of the injury, with a spokesman only confirming that Sturridge would miss the Switzerland game and return to his club for treatment.
Considering Sturridge's importance to their team, Liverpool will be hoping their 25-year-old striker is not sidelined for a lengthy period.
England will also be hindered by the loss of Sturridge, who was one of only a handful of players to emerge from Wednesday night's narrow win over Norway with his reputation enhanced.
Manager Roy Hodgson, who came in for heavy criticism following his team's performance at Wembley, is now without 15 senior players for a qualifier he must win to boost the morale of the supporters who stayed away for that poorly-attended Norway game.
Ben Foster and Jack Colback had already pulled out of the 22-man squad before Sturridge suffered his injury.
Hodgson will not call up any replacements so just 19 players - two of whom are goalkeepers - will travel to Switzerland on Sunday morning.
If England manage to avoid any more injuries, six outfield players will be on the bench at St Jakob-Park, including Danny Rose and Calum Chambers, who are in the squad for the first time.
One positive for Hodgson is that in Danny Welbeck he already has a ready-made, confident replacement for Sturridge.
The substitute injected pace, invention and verve into what was, at the time, a dull performance from Roy Hodgson's side against Norway, who were defeated by Wayne Rooney's second-half penalty.
With Olivier Giroud out for three months because of an ankle injury, Welbeck is likely to slot straight into Arsene Wenger's starting XI following his £16million move from United.
Jack Wilshere backed his new Arsenal team-mate to have a successful season for club and country.
''He is a great addition for Arsenal and hopefully he will keep performing for England as well,'' the Arsenal and England midfielder said.
''He has got great enthusiasm, he wants to run, he will track back, and he has got great quality.
''A lot of people don't give him credit for his technical ability, but he is great on the ball. I am sure there were a few clubs wanting him and there are not many players his age who move from one big club to another big club - so that shows his quality.''
Just 40,181 people turned up to watch the victory against Norway but Wilshere thinks England can start to win the fans back by beating the Swiss in Basle on Monday night.
''Going over to Switzerland is a tough game but we know if we put in the performance and get the result the fans are going to come back on our side,'' said Wilshere, who thinks the negative reaction to England's winless World Cup campaign has been over the top.
''If people analysed it a bit more they would have been a bit kinder, there were just a few individual errors and a few lapses in concentration - but at that level that is what you are going to get.
''When you are playing against (Mario) Balotelli and (Luis) Suarez that is what you are going to get, they are going to punish you - and they did.
''But if you look at the games, we had more positives than people give us credit for.''